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Lawrence C Paoletti

Associate Professor of Medicine, Brigham and Women's Hospital

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Latest Publications

A fluorescence-based opsonophagocytosis assay to measure the functional activity of antibody to group B Streptococcus.
Guttormsen HK, Mascuch SJ, West JC, Paoletti LC
Neither antibody to a group B streptococcal conjugate vaccine nor the vaccine itself is teratogenic in rabbits.
Paoletti LC, Guttormsen HK, Christian MS, Hoberman AM, Mcinnes P
Functional activity of antisera to group B streptococcal conjugate vaccines measured with an opsonophagocytosis assay and HL-60 effector cells.
Guttormsen HK, Liu Y, Paoletti LC

About

Research

My research has focused on the development of vaccines against group B Streptococcus (GBS), an opportunistic human pathogen. Over the past 2 decades, we have advanced GBS vaccines from development, and concept phases to advanced clinical trials with use of a GMP-prepared lot of vaccine. All vaccines were well-tolerated and induced protective levels of functional antibody.

Background